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Table 8 Effect of Bacillus coagulans on immune-related gene expressions in the jejunum of broilers challenged with NE (n = 6)

From: Effects of Bacillus coagulans supplementation on the growth performance and gut health of broiler chickens with Clostridium perfringens-induced necrotic enteritis

Items NEc MUC2 TLR2 TLR4 IFN-γ TNFSF15 LYZ Fowlicidin-2
7 DPId 14 DPI 7 DPI 14 DPI 7 DPI 14 DPI 7 DPI 14 DPI 7 DPI 14 DPI. 7 DPI 14 DPI 7 DPI 14 DPI
Bacillus coagulans, mg/kg
 0 1.17 0.79 1.01 1.07 1.04 1.19 1.06 1.01 1.01 1.18 1.16 1.10 1.07 1.53
 0 + 1.02 0.36 0.48 0.30 0.62 0.43 2.36 1.22 0.58 0.25 0.76 0.25 0.85 0.54
 400 1.47 0.94 0.90 1.05 0.99 1.12 0.95 0.86 1.09 1.35 1.65 0.84 1.70 1.79
 400 + 1.09 0.49 0.50 0.46 0.39 0.62 2.58 0.74 0.79 0.39 1.71 0.46 0.64 1.13
 SEMe   0.101 0.077 0.058 0.054 0.053 0.120 0.206 0.089 0.074 0.070 0.133 0.072 0.107 0.188
Main effect
 400   1.28 0.71 0.70 0.76 0.69 0.87 1.77 0.80 0.94 0.87 1.68a 0.65 1.17 1.46
 0   1.09 0.57 0.74 0.69 0.83 0.81 1.71 1.12 0.79 0.72 0.96b 0.67 0.96 1.04
 Challenged   1.05 0.42b 0.49b 0.38b 0.50b 0.52b 2.47a 0.98 0.68b 0.32b 1.23 0.36b 0.74b 0.83b
 Non-challenged   1.32 0.86a 0.95a 1.06a 1.01a 1.15a 1.01b 0.94 1.05a 1.27a 1.40 0.97a 1.39a 1.66a
P-valuesf
Bacillus coagulans   0.370 0.367 0.714 0.531 0.191 0.804 0.892 0.089 0.335 0.289 0.011 0.870 0.335 0.268
 Challenged   0.204 0.008 <0.001 <0.001 <0.001 0.014 0.001 0.804 0.020 <0.001 0.527 <0.001 0.006 0.036
 Challenged × Bacillus coagulans   0.562 0.935 0.594 0.397 0.393 0.603 0.679 0.364 0.670 0.924 0.393 0.114 0.057 0.671
  1. a,bMeans within the same column with different superscripts differ significantly (P < 0.05)
  2. cNE = Co-challenged with Eimeria spp. and Clostridium perfringens; −, without NE challenge; +, with NE challenge
  3. dDPI = days post infection
  4. eSEM, standard error of the mean
  5. fP-values represent the main effect of the diet, the main effect of NE challenge, and the interaction between the dietary treatments and NE challenge