Treatmentb
| Principal component |
---|
1 | 2 | 3 | 4 | 5 |
---|
22.6% | 22.2% | 16.0% | 15.6% | 10.1% |
---|
CON | ā0.225 | 0.119 | 0.119 | 0.719 | 0.517 |
CONĀ +Ā BIN | ā0.019 | 0.006 | 0.390 | ā0.327 | ā0.455 |
DON | ā0.571 | 0.630 | ā0.366 | ā0.477 | 0.119 |
DONĀ +Ā BIN | 0.679 | ā0.630 | ā0.120 | 0.071 | ā0.151 |
P-value |
āMycotoxin | 0.68 | 0.88 | 0.29 | 0.36 | 0.92 |
āBinder | 0.10 | 0.12 | 0.58 | 0.56 | 0.18 |
āMycot. Ć Binder | 0.23 | 0.19 | 0.98 | 0.08 | 0.44 |
BW d14c
| Ā | Ā | 0.889 | Ā | Ā |
FD4 permeability | Ā | Ā | Ā | Ā | 0.974 |
OCLN | 0.813 | Ā | Ā | Ā | Ā |
CLDN-1 | 0.767 | Ā | 0.401 | Ā | Ā |
CLDN-2 | 0.343 | Ā | 0.335 | 0.754 | Ā |
CLDN-5 | Ā | 0.546 | 0.713 | Ā | Ā |
TLR-4 | Ā | 0.891 | Ā | Ā | Ā |
TNF-Ī± | 0.498 | 0.666 | Ā | Ā | ā0.300 |
IL-1Ī² | Ā | 0.866 | Ā | Ā | Ā |
IL-8 | Ā | Ā | Ā | 0.910 | Ā |
IAP | 0.856 | Ā | Ā | Ā | Ā |
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aRotation method: varimax with Kaiser normalisation; only correlations with |r|Ā >Ā 0.3 are indicated
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b
CON negative control diet (uncontaminated basal diet), CONĀ +Ā BIN negative control diet with 1Ā kg/t mycotoxin binder, DON negative control diet with DON, DONĀ +Ā BIN negative control diet with DON and 1Ā kg/t mycotoxin binder. Principal components scores of subjects were analysed by General Linear model with fixed factor mycotoxin addition, binder addition and the interaction
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c
BW body weight, CLDN-1 Claudin 1, CLDN-2 Claudin 2, CLDN-5 Claudin 5, FD4 FITC-dextran 4, IAP Intestinal alkaline phosphatase, IL-1Ī² Interleukin 1 beta, IL-8 Interleukin 8, OCLN Occludin, TLR-4 Toll like receptor 4, TNF-Ī± Tumor necrosis factor alpha