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Fig. 1 | Journal of Animal Science and Biotechnology

Fig. 1

From: Plasma and cerebrospinal fluid interleukin-1β during lipopolysaccharide-induced systemic inflammation in ewes implanted or not with slow-release melatonin

Fig. 1

Schematic diagram of the experimental design. At the beginning of May all the ewes (n = 14) were ovariectomized and implanted with an oestradiol (E2). Two weeks later, animals were implanted under general anaesthesia with stainless steel guide cannulae into the third ventricle and ewes were melatonin- (n = 7) or sham-implanted (n = 7). Approximately 40 d later, melatonin- and sham-implanted ewes were treated with lipopolysaccharide (LPS). Blood samples were collected for melatonin, cortisol albumin and IL-1β concentrations measurement. Cerebrospinal fluid (CSF) samples were collected for albumin and IL-1β concentrations measurement. The choroid plexuses were collected 6 h after LPS administration

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