Table 3 Log₂ back-transformed LSM of interactions between treatment (TRT) and incubation time (T) on gene transcription, SEM and P values for TRT × T

  CCL2

3 h

0.45^c

1.83^a,y

0.48^c,z

0.69^b,z

0.11

0.0040

6 h

0.53^c

1.41^a,z

0.61^c,y

0.94^b,y

  CCL5

3 h

1.40^c,z

1.45^bc,z

1.62^b

2.00^a

0.07

0.0018

6 h

1.91^y

1.72^y

1.68

1.83

  CXCL6

3 h

0.43^c

1.67^a

0.51^c,y

0.99^b

0.12

0.0274

6 h

0.44^c

1.49^a

0.32^d,z

0.93^b

  CXCL8

3 h

0.49^c

2.17^a,y

0.62^c,y

1.34^b,y

0.17

0.0085

6 h

0.52^b

1.24^a,z

0.30^c,z

0.70^b,z

  IL6

3 h

1.01^b

3.01^a

1.15^b

2.17^a

0.28

0.1423

6 h

1.57

2.33

1.41

1.66

  IFIT3

3 h

0.85^b,z

0.96^a,z

0.96^a,z

1.05^a,z

0.05

0.5151

6 h

1.19^b,y

1.34^a,y

1.48^a,y

1.47^a,y

  IRF3

3 h

0.94^b,z

1.01^z

0.99^z

1.12^a

0.07

0.3942

6 h

1.18^y

1.18^y

1.28^y

1.26

  MYD88

3 h

1.64^b,z

1.95^a,z

1.67^b,z

2.02^a

0.05

0.7335

6 h

1.82^b,y

2.16^a,y

1.96^b,y

2.20^a

  NFKB1

3 h

0.93^b,z

1.18^a,z

1.12^a,z

1.21^a,z

0.06

0.5318

6 h

1.37^c,y

1.88^a,y

1.62^b,y

1.90^a,y

  PTGS2

3 h

0.85^b,z

1.12^a,z

1.07^a,z

1.12^a,z

0.07

0.2535

6 h

1.31^b,y

1.50^y

1.63^a,y

1.48^y

  TLR2

3 h

9.46

10.76

10.80

11.41

0.12

0.2028

6 h

11.41

12.04

9.47

11.07

  TLR4

3 h

0.99^c

1.42^a

1.28^ab,y

1.08^bc,z

0.10

<0.0001

6 h

1.09^b

1.57^a

0.85^c,z

1.37^a,y

  TOLLIP

3 h

0.96^b

0.97^b

1.03^a

0.97^b

0.03

0.3689

6 h

0.96^b

0.94^b

1.06^a

0.94^b