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Table 2 Haplotypes constituted by mitochondrial non-synonymous mutations in multiple levels and significant effects on litter size

From: Mitochondrial DNA T7719G in tRNA-Lys gene affects litter size in Small-tailed Han sheep

Functional haplotypea

Contained gene

Contained mutation number

Haplotype number

Significanceb

H

ND1, ND2, ND4L, ND4, ND5, ND6, COII, COIII, ATP6, 12SrRNA, 16SrRNA, tRNA-Tyr, tRNA-Lys, tRNA-His, tRNA-Ser

31

44

ns

H-ETC

ND1, ND2, ND4L, ND4, ND5, ND6, COII, COIII, ATP6

19

35

ns

H-MRCI

ND1, ND2, ND4L, ND4, ND5, ND6

15

33

ns

H-MRCIV

COII, COIII

2

3

ns

H-MRCV

ATP6

2

3

ns

H-ND4L

ND4L

2

4

ns

H-ND4

ND4

2

4

ns

H-ND5

ND5

2

3

ns

H-ND6

ND6

7

10

ns

H-ATP6

ATP6

2

3

ns

H-12SrRNA

12SrRNA

3

4

ns

H-16SrRNA

16SrRNA

5

15

ns

  1. aThe general haplotype (H) was assembled by all non-synonymous mutations to reflect the integrated characteristics of mtDNA coding regions. Subsequently, the ETC based haplotype (H-ETC) represented the general feature of all ETC-contained mtDNA sequences. The MRC based haplotype (H-MRC) inferred the integrated signal of particular MRC-contained mtDNA sequences. Here, H-MRC included three types, i.e. MRC-I, MRC-IV and MRC-V. The last was the gene-level haplotype (H-gene), which indicated the information of a particular gene-contained mtDNA sequence
  2. bWhen a set of statistical inferences were simultaneously considered, multiple comparisons were conducted by the FDR using the R project. “ns” represents “not significant”, and “*” represents “significant” at the significant level of 0.05