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Table 2 Haplotypes constituted by mitochondrial non-synonymous mutations in multiple levels and significant effects on litter size

From: Mitochondrial DNA T7719G in tRNA-Lys gene affects litter size in Small-tailed Han sheep

Functional haplotypea Contained gene Contained mutation number Haplotype number Significanceb
H ND1, ND2, ND4L, ND4, ND5, ND6, COII, COIII, ATP6, 12SrRNA, 16SrRNA, tRNA-Tyr, tRNA-Lys, tRNA-His, tRNA-Ser 31 44 ns
H-ETC ND1, ND2, ND4L, ND4, ND5, ND6, COII, COIII, ATP6 19 35 ns
H-MRCI ND1, ND2, ND4L, ND4, ND5, ND6 15 33 ns
H-MRCIV COII, COIII 2 3 ns
H-MRCV ATP6 2 3 ns
H-ND4L ND4L 2 4 ns
H-ND4 ND4 2 4 ns
H-ND5 ND5 2 3 ns
H-ND6 ND6 7 10 ns
H-ATP6 ATP6 2 3 ns
H-12SrRNA 12SrRNA 3 4 ns
H-16SrRNA 16SrRNA 5 15 ns
  1. aThe general haplotype (H) was assembled by all non-synonymous mutations to reflect the integrated characteristics of mtDNA coding regions. Subsequently, the ETC based haplotype (H-ETC) represented the general feature of all ETC-contained mtDNA sequences. The MRC based haplotype (H-MRC) inferred the integrated signal of particular MRC-contained mtDNA sequences. Here, H-MRC included three types, i.e. MRC-I, MRC-IV and MRC-V. The last was the gene-level haplotype (H-gene), which indicated the information of a particular gene-contained mtDNA sequence
  2. bWhen a set of statistical inferences were simultaneously considered, multiple comparisons were conducted by the FDR using the R project. “ns” represents “not significant”, and “*” represents “significant” at the significant level of 0.05