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Table 6 Groups of significant clusters in each comparison with indication of the Benjamini-Hochberg-corrected P-values (significance threshold: P < 0.05) and the number of genes in common among the three comparisons (see Table 7). Clusters were produced using DAVID database

From: Breed and adaptive response modulate bovine peripheral blood cells’ transcriptome

Annotation Cluster

# Genes

Function terms

Corrected P-value

# Common genes

APP+ vs. APP-

  

 C1

162

Purine nucleotide binding

0.001

2

 C2

44

Cytoplasmic vesicle

0.003

1

 C3

37

Cell fraction

0.009

2

 C4

15

Positive regulation of cytokine production

0.009

N.A.

 C5

150

Glycoprotein

0.016

23

 C6

32

Response to wounding

0.018

1

 C7

21

Regulation of cytokine production

0.026

1

 C8

25

Leukocyte activation

0.029

N.A.

IH APP+ vs. IH APP-

  

 CH1

11

Tyrosine protein kinase

0.003

N.A.

 CH2

72

Purine nucleotide binding

0.005

2

 CH3

21

Protein dimerization activity

0.006

N.A.

 CH4

83

Glycoprotein

0.006

23

 CH5

23

Cytoplasmic vesicle

0.035

1

IS APP+ vs. IS APP-

  

 CS1

6

Calcium-binding region

0.004

N.A.

 CS2

5

Anchored to membrane

0.016

3

 CS3

7

Enzyme inhibitor activity

0.017

1

 CS4

21

Extracellular space

0.018

12

 CS5

5

Negative regulation of molecular function

0.018

N.A.

 CS6

3

Cytokine biosynthetic process

0.019

1

 CS7

27

Glycoprotein

0.024

19

 CS8

42

Glycoprotein

0.025

23

 CS9

10

Positive regulation of molecular function

0.030

4

 CS10

15

Organelle lumen

0.033

1

 CS11

4

Response to steroid hormone stimulus

0.034

2

 CS12

5

Nuclear membrane

0.039

1