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Table 6 Groups of significant clusters in each comparison with indication of the Benjamini-Hochberg-corrected P-values (significance threshold: P < 0.05) and the number of genes in common among the three comparisons (see Table 7). Clusters were produced using DAVID database

From: Breed and adaptive response modulate bovine peripheral blood cells’ transcriptome

Annotation Cluster # Genes Function terms Corrected P-value # Common genes
APP+ vs. APP-   
 C1 162 Purine nucleotide binding 0.001 2
 C2 44 Cytoplasmic vesicle 0.003 1
 C3 37 Cell fraction 0.009 2
 C4 15 Positive regulation of cytokine production 0.009 N.A.
 C5 150 Glycoprotein 0.016 23
 C6 32 Response to wounding 0.018 1
 C7 21 Regulation of cytokine production 0.026 1
 C8 25 Leukocyte activation 0.029 N.A.
IH APP+ vs. IH APP-   
 CH1 11 Tyrosine protein kinase 0.003 N.A.
 CH2 72 Purine nucleotide binding 0.005 2
 CH3 21 Protein dimerization activity 0.006 N.A.
 CH4 83 Glycoprotein 0.006 23
 CH5 23 Cytoplasmic vesicle 0.035 1
IS APP+ vs. IS APP-   
 CS1 6 Calcium-binding region 0.004 N.A.
 CS2 5 Anchored to membrane 0.016 3
 CS3 7 Enzyme inhibitor activity 0.017 1
 CS4 21 Extracellular space 0.018 12
 CS5 5 Negative regulation of molecular function 0.018 N.A.
 CS6 3 Cytokine biosynthetic process 0.019 1
 CS7 27 Glycoprotein 0.024 19
 CS8 42 Glycoprotein 0.025 23
 CS9 10 Positive regulation of molecular function 0.030 4
 CS10 15 Organelle lumen 0.033 1
 CS11 4 Response to steroid hormone stimulus 0.034 2
 CS12 5 Nuclear membrane 0.039 1