Novel SNPs in IL-17F and IL-17A genes associated with somatic cell count in Chinese Holstein and Inner-Mongolia Sanhe cattle

Table 6 The additive and dominant effects of the SNPs on SCS and cytokines in Chinese Holstein and Sanhe cattle

SNPs		Effect^∞	SCS	IL-4,	IL-6,	IL-17,	IFN-γ,	TNF-α,
SNPs	Breed	Effect^∞	SCS	ng/mL	pg/mL	pg/mL	pg/mL	pg/mL
IL-17 F	Holstein	A	0.66 ± 0.44	−0.04 ± 0.05	−0.30 ± 5.87	−1.32 ± 0.71	0.52 ± 1.73	0.03 ± 0.05
g.24392436 C > T	P value		0.14	0.43	0.96	0.06	0.76	0.56
		D	−0.30 ± 0.59	0.01 ± 0.06	4.68 ± 7.69	−1.30 ± 0.92	−1.60 ± 2.26	0.03 ± 0.06
	P value		0.61	0.88	0.54	0.16	0.48	0.67
	Sanhe	A	0.02 ± 0.35	−0.01 ± 0.03	−5.53 ± 4.31	−2.65 ± 0.98	−0.26 ± 1.47	0.05 ± 0.04
	P value		0.95	0.84	0.20	<0.01	0.85	0.19
		D	0.19 ± 0.49	0.01 ± 0.04	−3.71 ± 6.02	−4.04 ± 1.31	−1.04 ± 2.06	0.03 ± 0.06
	P value		0.69	0.84	0.53	<0.01	0.61	0.62
IL-17A	Holstein	A	0.07 ± 0.27	−0.04 ± 0.03	0.37 ± 3.81	−0.24 ± 0.46	−1.08 ± 1.12	−0.002 ± 0.03
g.24345410 A > G	P value		0.78	0.20	0.92	0.59	0.34	0.96
		D	0.27 ± 0.41	0.12 ± 0.04	−5.51 ± 5.43	0.81 ± 0.66	1.23 ± 1.60	−0.02 ± 0.04
	P value		0.51	<0.01	0.31	0.22	0.44	0.59
	Sanhe	A	0.23 ± 0.22	−0.02 ± 0.02	−5.72 ± 2.68	−1.00 ± 0.60	−0.96 ± 0.92	0.01 ± 0.025
	P value		0.3	0.36	<0.05	0.10	0.3	0.79
		D	−0.65 ± 0.37	0.08 ± 0.03	−1.50 ± 4.55	−0.81 ± 1.01	0.88 ± 1.57	0.01 ± 0.0412
	P value		0.08	<0.01	0.74	0.42	0.57	0.31

ISSN: 2049-1891