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Table 6 Effect of supplementing AGP, feed enzymes (ENZ) and yeast extract (YE) without or with ENZ on the rectal temperature (°C), concentration of serum (pg/mL) cytokines and fold changes (log2) of ileal immune cytokines of weaned piglets challenged with E. coli LPS

From: Short-term effect of supplemental yeast extract without or with feed enzymes on growth performance, immune status and gut structure of weaned pigs challenged with Escherichia coli lipopolysaccharide

   LPS treatmentsb   Factorialc Contrast
Item NCCa AGP CC YE ENZ YE + ENZ SEM Main effect YE Main effect ENZ YE × ENZ NCC vs CC AGP vs CC AGP vs YE AGP vs ENZ AGP vs YE + ENZ
Rectal temperature
 Pre-challenge 38.9 39.2 39.1 39.0 39.2 39.2 0.13 NS 0.06 NS NS NS NS NS NS
 6 h post-challenge 39.2 39.9 39.9 39.8 40.1 40.1 0.15 NS NS NS 0.003 NS NS NS NS
Serum TNF-α
 Pre-challenge 98 88 96 77 102 93 9.3 NS NS NS NS NS NS NS NS
 6 h post-challenge 111 1032 1369 854 1621 933 120.8 0.001 NS NS <.0001 0.07 0.85 0.003 NS
Serum IL-10
 Pre-challenge 18 16 29 22 36 27 15.1 NS NS NS NS NS NS NS NS
 6 h post-challenge 16 157 99 153 86 156 15.3 0.004 NS NS 0.001 0.02 NS NS NS
Ileum cytokines, 96 h post-challenge
 IFN-γ 1.00 1.54 1.46 1.51 2.15 0.54 0.152 <.0001 NS <.0001 0.04 NS NS 0.008 <.0001
 TNF-α 1.00 2.52 2.40 1.37 1.60 1.41 0.244 0.013 0.099 0.073 0.0003 NS 0.002 0.013 0.003
 IL-1β 1.00 0.95 1.63 1.02 0.77 0.58 0.154 0.025 0.001 NS 0.01 0.004 NS NS NS
 IL-6 1.00 0.86 0.85 0.83 0.69 1.12 0.130 NS NS NS NS NS NS NS NS
 IL-10 1.00 0.60 1.31 0.74 0.71 0.76 0.123 0.033 0.019 0.012 0.09 0.0003 NS NS NS
  1. a NCC non-challenged control pigs that were fed the basal diet and injected with sterile saline on d 7
  2. bPigs fed the basal diet without any additive (CC challenged control) or with AGP, YE, ENZ or ENZ + YE and injected with E. coli LPS on d 7
  3. c P-value for LPS + ENZ × LPS + YE interaction (CC, YE, ENZ and ENZ + YE)