Table 1 Molecular sensors, microbial component and intracellular signalling pathways involved in the induction of HSPs by intestinal epithelial cells (adapted from ref. [34])
From: Microbiota-host interplay at the gut epithelial level, health and nutrition
Molecular sensor/receptor on intestinal epithelial cell | Microbial component recognized | Signalling pathway involved |
|---|---|---|
TLR-2 | Lipoteichoic acid | ? |
TLR-4 | Lipopolysaccharide | MAPK p38, ERK1/2 |
TLR-5 | Flagellin | MAPK p38 |
GPR-41 & GPR-43 (putatively) | Butyrate, propionate | ? |
PepT1 | fMLP peptide | MAPK p38 |
OCTN-2 | ERGMT peptide | MAPK p38 |
Integrin-β | Polyphosphate chains | MAPK p38 |