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Table 4 The effects of acetylsalicylic acid (ASA) and vitamin E (Vit E) on performance and indices of post-weaning colibacillosis measured for 21 d after weaning in E. coli-infected pigsa

From: Acetylsalicylic acid supplementation improves protein utilization efficiency while vitamin E supplementation reduces markers of the inflammatory response in weaned pigs challenged with enterotoxigenic E. coli

  ASA (A), ppm   Vit E (E), IU   P-value
  0 125 SEM 50 100 200 SEM A E A × E
D 0 – 14
 ADG, g/d 154 173 5.4 175 163 152 5.4 0.034 0.119 0.375
 ADFI, g/d 180 182 5.2 190 181 171 5.2 0.998 0.090 0.503
 G:F 0.87 0.94 0.022 0.93 0.90 0.88 0.022 0.087 0.587 0.175
D 0 – 21
 ADG, g/d 234 245 5.6 250 240 230 5.6 0.218 0.183 0.614
 ADFI, g/d 279 288 6.4 290 280 280 6.4 0.469 0.678 0.867
 G:F 0.86 0.87 0.013 0.87 0.86 0.86 0.013 0.742 0.894 0.412
 Diarrhoea index, %b 8.2 6.0 0.78 7.1 6.4 7.8 0.79 0.126 0.701 0.043
 Antibioticc 1.8 1.7 0.16 1.8 1.8 1.7 0.17 0.724 0.910 0.023
E. coli scored 8.0 6.3 0.79 7.4 5.8 8.2 0.79 0.009 0.002 0.391
  1. aAll pigs were experimentally infected with an enterotoxigenic strain of E. coli on 7, 8 and 9 d after weaning. The numbers of replications were 32 individual pigs up to d 10 and 24 pigs from d 14 to 21
  2. bDiarrhea index, %; mean percentage of days with diarrhea with respect to first 14 d after weaning. Significant interaction (P < 0.05) occurred between ASA and Vit E for the diarrhoea index, such that supplementation of 200 IU Vit E/kg diet decreased diarrhoea index but only with concurrent supplementation of 125 ppm ASA
  3. cMean number of antibiotic treatments. Significant interaction (P < 0.05) occurred between ASA and Vit E for the number of antibiotic treatments, such that supplementation of 200 IU Vit E/kg diet decreased the number of antibiotic treatments but only with concurrent supplementation of 125 ppm ASA
  4. dMean cumulative E. coli scores per diet in the 14 d after weaning