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Table 5 Effect of h[Gly2]GLP-21-34 on enzyme activity in the small intestine of LPS-challenged weaned pigletsa

From: The prolonged effect of glucagon-like peptide 2 pretreatment on growth performance and intestinal development of weaned piglets

Item Treatmentb Pooled SEM Contrastc
  Control LPS LPS + Low GLP-2 LPS + High GLP-2 1 2 3
Duodenum
Na+-K+-ATPase, U/mg protein 541 511 536 522 18 0.573 0.636 0.828
AKP, U/mg protein 47.6 27.3 42.1 49.6 1.8 <0.001 <0.001 <0.001
γ-GT, U/g protein 1,035 872 1,015 1,117 30 0.045 0.079 0.004
Amylase, U/mg protein 74.5 67.6 74.3 76.3 1.3 0.060 0.068 0.019
Lipase, U/mg protein 17,777 15,227 17,792 19,608 435 0.020 0.019 <0.001
Jejunum
Na+-K+-ATPase, U/mg protein 566 524 524 532 13 0.275 0.996 0.829
AKP, U/mg protein 15.4 12.4 14.4 16.5 0.5 0.047 0.178 0.007
γ-GT, U/g protein 988 818 945 1,013 26 0.019 0.075 0.008
Amylase, U/mg protein 154 144 166 161 4.7 0.467 0.103 0.215
Lipase, U/mg protein 48,436 38,616 44,289 52,209 1695 0.031 0.204 0.004
  1. aGLP-2 = Glucagon-like peptide 2; LPS = Escherichia coli lipopolysaccharide; AKP = Alkaline phosphatase; γ-GT = γ-Glutamyltranspeptidase
  2. bControl: piglets injected with sterile saline on d 14 postweaning; LPS: pigs challenged by LPS on d 14 postweaning; LPS + Low and LPS + High GLP-2: piglets pretreated with GLP-2 at doses of 2 and 10 nmol/kg BW per day for the first 7 d after weaning were challenged by LPS on d 14 postweaning. The data were obtained 24 h after injection with LPS and 15 d post-weaning
  3. cContrast: (1) control v. LPS; (2) LPS v. LPS + Low GLP-2; (3) LPS v. LPS + High GLP-2; Values are means of ten replicates