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Table 3 The effect of h[Gly2]GLP-21-34 on the weight of intestinal segment in weaned piglets post-LPS challengea

From: The prolonged effect of glucagon-like peptide 2 pretreatment on growth performance and intestinal development of weaned piglets

Item Treatmentb Pooled SEM Contrastc
  Control LPS LPS + Low GLP-2 LPS + High GLP-2 1 2 3
Duodenum, g 17.8 15.2 17.4 17.9 0.4 0.008 0.019 0.005
Jejunum, g 325 287 323 342 7 0.034 0.042 0.003
Ileum, g 43.8 38.5 42.2 47.1 1 0.035 0.134 0.001
Gross weight of SI, g 386 340 383 407 7 0.017 0.026 0.001
SI weight index 0.0402 0.0362 0.0385 0.0402 0.0006 0.016 0.147 0.015
  1. aGLP-2 = Glucagon-like peptide 2; LPS = Escherichia coli lipopolysaccharide; SI = Small intestine; SI weight index = Gross weight of SI/BW
  2. bControl: piglets injected with sterile saline on d 14 postweaning; LPS: pigs challenged by LPS on d 14 postweaning; LPS + Low and LPS + High GLP-2: piglets pretreated with GLP-2 at doses of 2 and 10 nmol/kg BW per day for the first 7 d after weaning were challenged by LPS on d 14 postweaning. The data were obtained 24 h after injection with LPS and 15 d post-weaning
  3. cContrast: (1) control v. LPS; (2) LPS v. LPS + Low GLP-2; (3) LPS v. LPS + High GLP-2; Values are means of ten replicates