The prolonged effect of glucagon-like peptide 2 pretreatment on growth performance and intestinal development of weaned piglets

Table 3 The effect of h[Gly2]GLP-2_1-34 on the weight of intestinal segment in weaned piglets post-LPS challenge^a

Item	Treatment^b				Pooled SEM	Contrast^c
	Control	LPS	LPS + Low GLP-2	LPS + High GLP-2	Pooled SEM	1	2	3
Duodenum, g	17.8	15.2	17.4	17.9	0.4	0.008	0.019	0.005
Jejunum, g	325	287	323	342	7	0.034	0.042	0.003
Ileum, g	43.8	38.5	42.2	47.1	1	0.035	0.134	0.001
Gross weight of SI, g	386	340	383	407	7	0.017	0.026	0.001
SI weight index	0.0402	0.0362	0.0385	0.0402	0.0006	0.016	0.147	0.015

^aGLP-2 = Glucagon-like peptide 2; LPS = Escherichia coli lipopolysaccharide; SI = Small intestine; SI weight index = Gross weight of SI/BW
^bControl: piglets injected with sterile saline on d 14 postweaning; LPS: pigs challenged by LPS on d 14 postweaning; LPS + Low and LPS + High GLP-2: piglets pretreated with GLP-2 at doses of 2 and 10 nmol/kg BW per day for the first 7 d after weaning were challenged by LPS on d 14 postweaning. The data were obtained 24 h after injection with LPS and 15 d post-weaning
^cContrast: (1) control v. LPS; (2) LPS v. LPS + Low GLP-2; (3) LPS v. LPS + High GLP-2; Values are means of ten replicates

ISSN: 2049-1891