Skip to main content

Table 2 The effect of h[Gly2]GLP-21-34 on plasma GLP-2 concentrations in weaned piglets before LPS challengea (pg/mL)

From: The prolonged effect of glucagon-like peptide 2 pretreatment on growth performance and intestinal development of weaned piglets

Item

Treatmentb

Pooled SEM

Contrastd

 

Control

LPS

LPS + Low GLP-2

LPS + High GLP-2

1

2

3

d 0

199.8

202.1

200.7

201.6

1.7

0.646

0.773

0.921

d 7

169.4

164.2

179.9

195.2

2.2

0.120

<0.001

<0.001

d 14

195.1

190.6

210.4

230.1

3.1

0.397

0.001

<0.001

Pooled SEM

2.9

3.3

3.0

3.5

--

--

--

--

Contrastc

1

<0.001

<0.001

<0.001

0.522

--

--

--

 

2

<0.001

<0.001

<0.001

<0.001

--

--

--

 

3

0.231

0.006

0.055

<0.001

--

--

--

 
  1. aGLP-2 = Glucagon-like peptide 2; LPS = Escherichia coli lipopolysaccharide
  2. bControl: non-challenged control; LPS: pigs injected with sterile PBS solution containing 0 nmol/kg BW human GLP-2; LPS + Low and LPS + High GLP-2: piglets injected with PBS solution containing h[Gly2]GLP-21-34 at doses of 2 and 10 nmol/kg BW per day for the first 7 d after weaning. The data were obtained before LPS challenge
  3. cContrast: (1) 0 d v. 7 d; (2) 7 d v. 14 d; (3). 0 d v.14 d
  4. dContrast: (1) control v. LPS; (2) LPS v. LPS + Low GLP-2; (3) LPS v. LPS + High GLP-2; Values are means of ten replicates