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Table 2 The effect of h[Gly2]GLP-21-34 on plasma GLP-2 concentrations in weaned piglets before LPS challengea (pg/mL)

From: The prolonged effect of glucagon-like peptide 2 pretreatment on growth performance and intestinal development of weaned piglets

Item Treatmentb Pooled SEM Contrastd
  Control LPS LPS + Low GLP-2 LPS + High GLP-2 1 2 3
d 0 199.8 202.1 200.7 201.6 1.7 0.646 0.773 0.921
d 7 169.4 164.2 179.9 195.2 2.2 0.120 <0.001 <0.001
d 14 195.1 190.6 210.4 230.1 3.1 0.397 0.001 <0.001
Pooled SEM 2.9 3.3 3.0 3.5 -- -- -- --
Contrastc 1 <0.001 <0.001 <0.001 0.522 -- -- --  
2 <0.001 <0.001 <0.001 <0.001 -- -- --  
3 0.231 0.006 0.055 <0.001 -- -- --  
  1. aGLP-2 = Glucagon-like peptide 2; LPS = Escherichia coli lipopolysaccharide
  2. bControl: non-challenged control; LPS: pigs injected with sterile PBS solution containing 0 nmol/kg BW human GLP-2; LPS + Low and LPS + High GLP-2: piglets injected with PBS solution containing h[Gly2]GLP-21-34 at doses of 2 and 10 nmol/kg BW per day for the first 7 d after weaning. The data were obtained before LPS challenge
  3. cContrast: (1) 0 d v. 7 d; (2) 7 d v. 14 d; (3). 0 d v.14 d
  4. dContrast: (1) control v. LPS; (2) LPS v. LPS + Low GLP-2; (3) LPS v. LPS + High GLP-2; Values are means of ten replicates