The prolonged effect of glucagon-like peptide 2 pretreatment on growth performance and intestinal development of weaned piglets

Table 1 The effect of h[Gly2]GLP-2_1-34 on the growth of weaned piglets before LPS challenge^a

Item	Treatment^b				Pooled SEM	Contrast^c
	Control	LPS	LPS + Low GLP-2	LPS + High GLP-2	Pooled SEM	1	2	3
Initial BW, kg	6.78	6.82	6.82	6.78	0.068	0.824	0.980	0.844
Final BW, kg	9.61	9.41	9.98	10.11	0.11	0.499	0.061	0.022
d 0 to 7
ADFI, g/d	320	321	320	312	7	0.966	0.943	0.691
ADG, g/d	183	174	205	203	5	0.465	0.013	0.019
G:F	0.574	0.543	0.645	0.656	0.012	0.237	<0.001	<0.001
d 7 to 14
ADFI, g/d	379	355	380	394	9	0.360	0.340	0.148
ADG, g/d	221	195	245	272	10	0.306	0.052	0.004
G:F	0.583	0.544	0.634	0.688	0.013	0.198	0.005	<0.001
d 0 to 14
ADFI, g/d	350	338	350	353	7	0.558	0.552	0.468
ADG, g/d	202	184	225	237	7	0.297	0.018	0.003
G:F	0.579	0.545	0.640	0.674	0.012	0.196	0.001	<0.001

^aGLP-2 = Glucagon-like peptide 2; LPS = Escherichia coli lipopolysaccharide
^bControl: non-challenged control; LPS: pigs injected with sterile PBS solution containing 0 nmol/kg BW human GLP-2; LPS + Low and LPS + High GLP-2: piglets injected with PBS solution containing h[Gly2]GLP-2_1-34 at doses of 2 and 10 nmol/kg BW per day for the first 7 d after weaning. The data were obtained before LPS challenge
^cContrast: (1) control v. LPS; (2) LPS v. LPS + Low GLP-2; (3) LPS v. LPS + High GLP-2; Values are means of ten replicates

ISSN: 2049-1891