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Table 1 The effect of h[Gly2]GLP-21-34 on the growth of weaned piglets before LPS challengea

From: The prolonged effect of glucagon-like peptide 2 pretreatment on growth performance and intestinal development of weaned piglets

Item Treatmentb Pooled SEM Contrastc
  Control LPS LPS + Low GLP-2 LPS + High GLP-2 1 2 3
Initial BW, kg 6.78 6.82 6.82 6.78 0.068 0.824 0.980 0.844
Final BW, kg 9.61 9.41 9.98 10.11 0.11 0.499 0.061 0.022
d 0 to 7   
ADFI, g/d 320 321 320 312 7 0.966 0.943 0.691
ADG, g/d 183 174 205 203 5 0.465 0.013 0.019
G:F 0.574 0.543 0.645 0.656 0.012 0.237 <0.001 <0.001
d 7 to 14   
ADFI, g/d 379 355 380 394 9 0.360 0.340 0.148
ADG, g/d 221 195 245 272 10 0.306 0.052 0.004
G:F 0.583 0.544 0.634 0.688 0.013 0.198 0.005 <0.001
d 0 to 14   
ADFI, g/d 350 338 350 353 7 0.558 0.552 0.468
ADG, g/d 202 184 225 237 7 0.297 0.018 0.003
G:F 0.579 0.545 0.640 0.674 0.012 0.196 0.001 <0.001
  1. aGLP-2 = Glucagon-like peptide 2; LPS = Escherichia coli lipopolysaccharide
  2. bControl: non-challenged control; LPS: pigs injected with sterile PBS solution containing 0 nmol/kg BW human GLP-2; LPS + Low and LPS + High GLP-2: piglets injected with PBS solution containing h[Gly2]GLP-21-34 at doses of 2 and 10 nmol/kg BW per day for the first 7 d after weaning. The data were obtained before LPS challenge
  3. cContrast: (1) control v. LPS; (2) LPS v. LPS + Low GLP-2; (3) LPS v. LPS + High GLP-2; Values are means of ten replicates