Occurrence of retained placenta is preceded by an inflammatory state and alterations of energy metabolism in transition dairy cows

Table 1 Data of dry matter intake, milk production, milk composition, and selected metabolites, cytokines, and APP in the serum of dairy cows with (n = 6) and without (n = 6) retained placenta (RP) during the periparturient period

	Group^a			Effect,^b P-value
Item	CON	RP	SEM	Hs	Wk	Hs × Wk
DMI^c, kg/d	18.64	16.45	0.56	0.02	<0.01	0.23
Milk production^d, kg/d	42.37	32.58	2.80	0.02	<0.01	0.07
Temperature, °C	38.43	38.42	0.05	0.88	<0.01	0.63
BCS	2.93	3.08	0.11	0.39	<0.01	074
Milk composition ^e, %, unless otherwise stated
Fat	3.84	3.80	0.22	0.91	0.33	0.28
Protein	2.88	2.92	0.10	0.77	<0.01	0.15
Fat:protein ratio	1.36	1.28	0.09	0.57	0.21	0.26
Lactose	4.56	4.49	0.04	0.35	0.04	0.49
SCC, 10³ cells/mL	30.83	50.79	4.2	0.01	0.22	0.30
Milk urea N, mg/dL	15.56	12.85	0.98	0.11	0.25	0.10
TS	12.21	13.65	0.68	0.22	0.29	0.56
Serum parameters ^f
Lactate, μmol/L	2,258	4502	456	0.01	0.27	0.36
NEFA, mmol/L	397.13	275.87	73.11	0.30	<0.01	0.50
BHBA, μmol/L	595.81	431.32	67.51	0.13	<0.01	0.14
IL-1, pg/mL	296.64	313.39	3.69	0.02	<0.01	0.53
IL-6, pg/mL	26.74	57.71	12.24	0.20	<0.01	<0.01
TNF-α, ng/mL	0.19	1.22	0.11	<0.01	0.42	0.68
Haptoglobin, mg/mL	0.15	0.36	0.07	0.10	0.16	0.10
SAA, ug/mL	8,477	23,165	2,311	<0.01	0.81	0.95

^aCON = cows without retained placenta (health control); RP = cows with retained placenta
^bEffect of health status (Hs), sampling week (Wk), and health status by sampling week interaction (Hs × Wk)
^cDry matter intake was calculated from week −8 to +8 relative to parturition
^dMilk production was calculated from week +1 to +8 relative to parturition
^eMilk compositions were determined on week +2, +3, +5, +7 relative to parturition
^fSerum parameters were calculated from week −8, −4, disease and +4 relative to parturition

ISSN: 2049-1891