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Table 8 The effects of dietary nucleotides supplementation on blood profiles of weaned pigs challenged with E. coli K88 (Exp. 2)a

From: Response to an Escherichia coli K88 oral challenge and productivity of weanling pigs receiving a dietary nucleotides supplement

Item CON R150 R220 R275 SEMb Contrastc
1 2 3
Before Challenge         
 Lymphocyte, % 25.49 30.15 30.92 33.08 1.95 0.01 0.30 0.77
 RBC, 106/μL 6.57 6.54 7.00 6.40 0.21 0.75 0.63 0.05
 WBC, 103/μL 16.13 17.91 17.73 18.41 0.91 0.08 0.70 0.70
 IgG, mg/dL 173.10 184.70 204.10 210.50 15.98 0.16 0.26 0.74
 IgA, mg/dL 41.00 45.00 44.40 45.50 1.44 0.02 0.81 0.63
 IgM, mg/dL 12.40 14.00 16.70 18.00 1.90 0.09 0.15 0.76
 Cortisol 3.47 2.71 2.41 2.22 0.26 0.002 0.19 0.87
 TNF-α 116.06 102.82 112.49 124.86 8.36 0.78 0.07 0.90
 IGF-I 123.55 148.08 142.95 153.42 11.17 0.07 0.74 0.57
 IL-6 19.68 20.49 20.62 19.93 0.79 0.47 0.62 0.68
After Challenge         
 Lymphocyte, % 29.30 19.90 29.50 30.89 5.36 0.69 0.16 0.53
 RBC, 106/μL 6.33 6.61 6.63 6.54 0.19 0.23 0.79 0.79
 WBC, 103/μL 17.33 23.89 18.70 20.92 1.71 0.06 0.23 0.09
 IgG, mg/dL 225.50 185.10 220.80 216.40 10.60 0.15 0.05 0.13
 IgA, mg/dL 41.90 42.80 44.80 46.20 0.78 0.01 0.004 0.76
 IgM, mg/dL 17.30 18.40 24.00 30.00 2.00 0.01 <0.001 0.93
 Cortisol 4.17 2.81 3.01 2.72 0.40 0.01 0.87 0.62
 TNF-α 173.43 157.33 155.89 148.74 5.82 0.01 0.31 0.69
 IGF-I 81.55 113.71 122.27 131.04 7.50 <0.001 0.11 0.99
 IL-6 28.23 27.31 25.59 21.51 1.53 0.06 0.01 0.53
  1. aAbbreviation: CON basal diet, R150 basal diet + nucleotides 150 mg/kg, R220 basal diet + nucleotides 220 mg/kg, R275 basal diet + nucleotides 275 mg/kg
  2. bStandard error mean
  3. cContrast: 1) CON vs. mean of nucleotide groups; 2) R150 vs. R275; 3) R220 vs. mean of R150 and R275