Fatty acids, inflammation and intestinal health in pigs

Liu, Yulan

doi:10.1186/s40104-015-0040-1

Journal of Animal Science and Biotechnology

Table 1 Summary of studies investigating the effect of fatty acids on intestinal health of pigs

From: Fatty acids, inflammation and intestinal health in pigs

Fatty acids	Effects	Animals	References
SCFA	↓Intestinal atrophy, ↑structural indices of GI adaptation, ↑enterocyte proliferation, ↓enterocyte apoptosis	TPN-fed neonatal pigs	[40]
	↓Diarrhoea incidence, ↑serum IgG concentration and jejunal IgA⁺ cell count	Weaned piglets	[42]
	↑ Intestinal morphology and disaccharidase activity	Newly weaned piglets	[43]
	↓Intestinal injury by ↓ apoptosis, ↑ tight-junction formation, ↑EGFR signaling	Pig model of acetic acid-induced colitis	[44]
	↑Recovering of intestinal wound healing	Porcine IPEC J2	[45]
	↑Intestinal morphology, ↓total viable counts of proximal colon Clostridium and Escherichia coli, ↓serum TNF-α and IL-6 levels, and intestinal DNA-binding activity of NF-κB	Weaned piglets	[46]
	↓Gastric emptying and intestinal mucosa weight	Piglets before or after weaning	[47]
	↑Host defense peptide gene expression	IPEC-J2	[48]
MCFA	↑Villus height, ↓crypt depth, ↓intraepithelial lymphocytes	Weaned pigs	[51]
	Affected gastric microbial ecology, altered intestinal SCFA concentrations	Weaned pigs	[55]
	↓Salmonella typhimurium	in vitro simulation of porcine cecum	[56]
n-3 PUFA	When fed to sow during gestation and lactation periods, enriches piglet tissues and ↑intestinal structure	Piglets	[65–71]
	↓Sensitivity of epithelial barrier to mast cell degranulation	Piglets	[65]
	↑Glucose absorption, ↑protein expression of glucose transporters	Newly weaned pigs	[67, 69]
	↑Intestinal morphology and barrier function, ↓TLR4 and NOD2 signaling	LPS-challenged piglets	[2]
	↑Transepithelial electrical resistance	Suckling pigs after ischemic injury	[74]
	↓Serum endotoxin concentration, ↓Ex vivo mucosal to serosal endotoxin transport	Growing pigs	[75]
ARA	↓Histological lesions, ↑transepithelial resistance recovery, ↓ mucosal-to-serosal flux	Suckling pigs after ischemic injury	[74]
CLA	↓Enteric damage and clinical signs, ↑PPARγ and PGC1α, ↓TNF-α	Pig model of DSS-induced colitis	[81]
	↓Mucosal damage and inflammation, ↑PPARγ, ↓IFNγ	Pig model of bacterial-induced colitis	[11, 82]
	↓Intestinal inflammation, ↑serum IgG and IgA	ETEC-challenged piglets	[83]

DSS dextran sodium sulfate, EGFR epidermal growth factor receptor, ETEC enterotoxigenic Escherichia coli, GI gastrointestinal, IFN Interferon, MCFA medium-chain fatty acid, NF-κB nuclear factor-κB, NOD2 nucleotide binding oligomerization domain protein 2, PGC1α PPAR γ-coactivator-1α, PPARγ proliferator-activated receptor-γ, PUFA polyunsaturated fatty acid, SCFA short-chain fatty acid, TLR4 toll-like receptor 4, TNF tumor necrosis factor, TPN total parenteral nutrition

Back to article page

ISSN: 2049-1891

Contact us

Submission enquiries: Access here and click Contact Us
General enquiries: info@biomedcentral.com