Bacteriophages as antimicrobial agents against major pathogens in swine: a review

Table 1 Effects of dietary supplementation with phages on pig performance

Diets		ADG, g	ADFI, g	G:F	Reference	Aims
BD¹		459	1284	0.36	Yan et al. [15]	Evaluate the effects of Salmonella phages on the performance of growing pigs
BD + 22 ppm tylosin		464	1231	0.38
BD + 0.025 % phage		455	1294	0.35
BD + 0.05 % phage		472	1272	0.37
BD		737	2079	0.35	Kim et al. [16]	Effects of dietary supplementation with phages, probiotics and a combination of the two on pig performance
BD + 0.5 g/kg phage		764	2129	0.36
BD + 1.0 g/kg phage		815	2240	0.36
BD + 1.5 g/kg phage		822	2222	0.37
Before challenge⁴	CON²	654	1688	0.39	Gebru et al. [17]	Effects of dietary supplementation with probiotic, anti- Salmonella typhimurium phage, organic acid combinations, or fermented soybean on pig performance
Before challenge⁴	AST³	627	1652	0.38
After challenge	CON	273^a	1,313^a	0.21^a
After challenge	AST	719^b	1,938^b	0.08^b

¹BD = Basal diet. ²CON = control diet with no added antimicrobial
³AST = 3 × 10⁹ PFU/kg anti-Salmonella typhimurium phage supplementation
⁴Values are calculated for the 2 weeks before Salmonella typhimurium challenge and the 2 weeks after challenge
^a,bMeans in the same column with different superscripts differ (P < 0.05)

ISSN: 2049-1891