Changes in fetal mannose and other carbohydrates induced by a maternal insulin infusion in pregnant sheep

Table 2 Eight-Wk maternal insulin infusion

Measurement	Control	Hypoglycemic	HG+I
Gestational age, d	133.2 ± 1.1	133.0 ± 1.3	134.5 ± 0.9
Maternal plasma arterial carbohydrates, μmol/L
Glucose	3,605 ± 203	1,715 ± 145**	1,817 ± 95**
Mannose	67.0 ± 4.3	34.7 ± 3.5**	31.4 ± 5.0**
Inositol	27.7 ± 4.4	34.9 ± 3.9	34.6 ± 3.1
Sorbitol	13.4 ± 3.4	18.8 ± 4.2	11.8 ± 1.3
Erythritol	52.8 ± 5.5	44.5 ± 3.1	39.6 ± 8.5
Arabinol	96.2 ± 13.3	125.6 ± 6.5	118.0 ± 23.3
Ribitol	25.6 ± 3.0	25.9 ± 3.2	16.1 ± 4.3
Fetal weight, kg	3.66 ± 0.12	2.20 ± 0.14**	2.61 ± 0.21**
Fetal plasma arterial insulin, ng/mL	0.46 ± 0.09	0.16 ± 0.03*	0.66 ± 0.17
Fetal plasma arterial carbohydrates, μmol/L
Glucose	1,553 ± 282	587 ± 56**	511 ± 37**
Mannose	30.4 ± 3.8	17.0 ± 1.1**	7.9 ± 0.9**
Inositol	741.4 ± 240.8	910.1 ± 157.5	792.2 ± 199.5
Sorbitol	188.5 ± 31.9	55.2 ± 11.9**	41.3 ± 8.3**
Fructose	4,508 ± 981	1,631 ± 301**	800 ± 154**
Erythritol	394.6 ± 30.7	372.2 ± 9.3	311.6 ± 24.6
Arabinol	235.3 ± 17.1	237.5 ± 15.1	214.9 ± 54.3
Ribitol	124.3 ± 15.9	139.6 ± 21.7	156.8 ± 57.6
Mannitol	47.4 ± 8.5	31.4 ± 6.1	33.8 ± 8.7
Fetal hepatic sorbitol and fructose, nmol/g
Sorbitol	589.0 ± 90.1	205.8 ± 42.1**	161.3 ± 56.0**
Fructose	1,679 ± 219	398 ± 119**	215 ± 95**

Values are means ± SEM. *, ** refer to significant differences from Control (n = 5) animals; P < 0.05, 0.01, respectively, by ANOVA.

ISSN: 2049-1891