Plasma metabolomic profiles and immune responses of piglets after weaning and challenge with E. coli

Table 3 List of metabolites identified in the metabolomic analysis ^a

Metabolites	Retention time, min	m/z	Mass accuracy, ppm	Fold change^b	Up/down	P value^c	FDR q value^c
L-Proline/D-Proline	9.81	116.0702	3.45	1.35	↑	0.0035	0.0046
Betaine	10.93	118.0857	5.08	1.60	↓	<0.0001	<0.0001
Taurine	7.15	126.0225	4.76	1.49	↑	0.0003	0.0005
Creatine	9.99	132.0760	6.06	3.35	↓	0.0002	0.0003
Carnitine	10.78	162.1116	5.55	1.45	↑	<0.0001	<0.0001
L-Arginine	11.02	175.1177	7.42	1.82	↓	<0.0001	<0.0001
Acetylcarnitine	10.71	204.1218	5.88	1.24	↓	0.0003	0.0005
LysoPC 14:0	9.49	468.3054	6.62	3.04	↑	<0.0001	<0.0001
LysoPC 16:1	9.39	494.3207	6.88	1.95	↓	<0.0001	<0.0001
LysoPC 16:0	9.31	496.3357	8.26	1.20	↓	<0.0001	<0.0001
LysoPC 16:0 [M + Na]⁺	9.32	518.3171	8.87	1.19	↓	0.0015	0.0021
LysoPC 18:2	9.31	520.3351	9.03	1.90	↓	<0.0001	<0.0001
LysoPC 18:0	9.07	524.3667	8.39	1.10	↓	0.0428	0.0397
LysoPC 17:0 [K + Na]⁺	9.17	548.3095	3.28	1.40	↑	<0.0001	<0.0001
UI PC	8.20	678.5028	5.90	19.75	↑	<0.0001	<0.0001
UI PC	8.05	758.5608	11.34	1.43	↓	<0.0001	<0.0001
UI PC	7.78	810.5916	11.23	1.31	↓	<0.0001	<0.0001
UI PC [M + Na]⁺	7.75	834.5922	7.31	1.26	↑	0.0001	0.0003

^aDiscriminating between day 0 and day 4 postweaning. ^bFold change was calculated by dividing the mean intensity of each plasma metabolite on day 4 postweaning by the mean intensity of the same plasma metabolite on day 0, calculated automatically by the XCMS Online system. ^cP values and FDR q values were calculated automatically by the XCMS Online system. UI, unidentified; PC, phosphatidylcholine; LysoPC, lysophosphatidylcholine; ↑, increased; ↓, decreased.

ISSN: 2049-1891