Fig. 8

Identification of candidate discriminant signatures. A Diagnostic plot reveals that the first component from all omics datasets were highly correlated. B Circos plot of identified discriminant signatures per omics. The plot represents the correlations greater than 0.7 between signatures of different omics. The color of internal connecting lines shows the positive (orange) and negative (green) correlations. The outer lines represent the expression levels of corresponding signatures in SM and HC groups, with the outer line representing a higher expression in the corresponding group. C Clustered heat map for all identified candidate discriminant signatures. D–G The loading weight of identified signatures from the omics datasets of dMHB (D), DEG (E), DEM (F), and DEL (G). The most important discriminant signatures with highest absolute loading weights are ordered from bottom to top. The color of the bar indicates the group for which the median expression value is the highest for corresponding signatures. SM: Subclinical mastitis, HC: Healthy control, DEG: Differentially expressed gene, DEL: Differentially expressed lncRNA, DEM: Differentially expressed miRNA, dMHB: Differential methylation haplotype block