Database | Pathway | P-value | Downregulated (↓)/ upregulated (↑) DAP |
---|---|---|---|
Gene Ontology | Actin filament polymerization | 0.0000 | ↓ RAC1, ARPC4, COTL1, VIL1, GSN, CTTN |
Barbed-end actin filament capping | 0.0015 | ↓ HSPB1, VIL1, GSN, CAPZA2 | |
Actin filament severing | 0.0046 | ↓ VIL1, GSN; ↑ DSTN | |
Actin cytoskeleton reorganization | 0.0092 | ↓ RAC1, MYH9, CTTN, EZR, ANXA1 | |
Actin filament-based movement | 0.0191 | ↓ MYH9, MYO6, MYO1A | |
Regulation of cell-cell adhesion mediated by integrin | 0.0433 | ↓ ADA; ↑ DPP4 | |
Epithelial cell differentiation | 0.0499 | ↓ ANXA4, BDH2, VIL1, HNRNPH3 | |
Reactome | Gap junction degradation | 0.0328 | ↓ MYO6, AP2M1, CLTC |
RHO GTPases activate PAKs | 0.0402 | ↓ RAC1, CDC42, MYLK | |
RHO GTPases Activate WASPs and WAVEs | 0.0464 | ↓ RAC1, CDC42, ARPC4, ACTR2 |