Fig. 5

Treatment with S. maltophilia altered immune and metabolic pathways in the mammary gland tissues. Mammary gland tissues were collected for transcriptome sequencing after the mice were treated with 10¹⁰ CFU S. maltophilia for a week. A Statistics of up and down frequency of differentially expressed genes. The number of differentially expressed genes up regulated (log₂FC ≥ 1 and Q < 0.05) and down regulated (log₂FC ≤ −1 and Q < 0.05) in each comparison group was counted. B Up and down histogram of GO enrichment. The ordinate represents the number of differential genes enriched to GO entries, the number of up and down genes is red and blue respectively, and the abscissa represents GO entries. C In the KEGG enrichment bubble chart, the abscissa Rich Factor represents the proportion of the number of differential genes located in the path to the total number of genes located in the path, and the ordinate is the KEGG pathway. D KEGG level histogram: the abscissa is the number of differential genes included in the pathway, and the color represents the KEGG primary classification