Fig. 5

The typical growth factor type ligand-receptor interactions predicted by iTALK between any two cell types. The network plot showed ligand-receptor interactions detected between each two different cell types. In the network, every node showed a cell type, and the thickness of the arrow lines represented the number of ligand-receptor interactions. The arrows labeled the forward (from signaling cell to target cell) and backward signals. The circos plot displayed the names of each ligand-receptor gene pair and the direction. The outside ring of circos plot exhibited cell types, and the inside ring of circos plot exhibited the details of each interaction ligand-receptor pair. The lines inside the circos plot indicated the relative signal strength of the ligand and receptor. The arrow indicated the receptor