Fig. 6

Role of BPA exposure in the inflammatory response and barrier function in the type A COT tissues within Hu ewes on d 130 of gestation. A Concentrations of factors (TNF-α, IL-1β and IL-6). B TER. C FD4. D Inflammatory response-related gene levels. E Typical immunoblots showing inflammatory response-related proteins. F Inflammatory response-related protein levels. G Barrier function-related gene levels. H Typical immunoblots showing barrier function-related proteins. I Barrier function-related protein levels. Data are presented as means ± SEM, n = 8. Means with no common letter are different (P < 0.05). BPA group, pregnant Hu ewes receiving Bisphenol A (5 mg/kg/d mixed sufficiently into corn oil) through subcutaneous injection; CON group, pregnant Hu ewes receiving corn oil only; COT, cotyledonary; FD4, paracellular dextran flux; IL, interleukin; MyD88, myeloid differentiation factor 88; NF-κB, nuclear factor kappa-B; TER, transepithelial electrical resistance; TNF, tumour necrosis factor; TLR, toll-like receptor; ZO-1, zonula occludens-1