The prolonged effect of glucagon-like peptide 2 pretreatment on growth performance and intestinal development of weaned piglets

Table 4 Effect of h[Gly2]GLP-2_1-34 pretreatment on the intestinal morphology of weaned pigs exposed to LPS^a

Item	Treatment^b				Pooled SEM	Contrast^c
	Control	LPS	LPS + Low GLP-2	LPS + High GLP-2	Pooled SEM	1	2	3
Duodenum
Villus height, μm	438	335	420	438	8	<0.001	<0.001	<0.001
Crypt depth, μm	242	257	264	237	3	0.094	0.415	0.027
VCR	1.81	1.31	1.60	1.85	0.04	<0.001	<0.001	<0.001
Jejunum
Villus height, μm	341	284	322	353	7	0.001	0.019	<0.001
Crypt depth, μm	210	207	227	212	3	0.708	0.017	0.477
VCR	1.63	1.38	1.43	1.67	0.03	0.005	0.607	0.002
Ileum
Villus height, μm	306	239	259	324	6	<0.001	0.041	<0.001
Crypt depth, μm	199.5	205.3	209.9	209.0	1.8	0.259	0.377	0.863
VCR	1.54	1.16	1.24	1.56	0.03	<0.001	0.237	<0.001

^aGLP-2 = Glucagon-like peptide 2; LPS = Escherichia coli lipopolysaccharide; VCR = Villus height/Crypt depth ratio
^bControl: piglets injected with sterile saline on d 14 postweaning; LPS: pigs challenged by LPS on d 14 postweaning; LPS + Low and LPS + High GLP-2: piglets pretreated with GLP-2 at doses of 2 and 10 nmol/kg BW per day for the first 7 d after weaning were challenged by LPS on d 14 postweaning. The data were obtained 24 h after injection with LPS and 15 d post-weaning
^cContrast: (1) control v. LPS; (2) LPS v. LPS + Low GLP-2; (3) LPS v. LPS + High GLP-2; Values are means of ten replicates

ISSN: 2049-1891