Table 2 Differentially expressed proteins in liver of HC and LC groups identified by two-dimensional gel electrophoresis analysis and MALDI-TOF-MSa,b
Spot number | Protein name | Accession number | Molecular weight, kDa | PI | Protein expression |
|---|---|---|---|---|---|
Oxidative stress (4) | |||||
 1 | Regucalcin (RNG) | gi|195972815 | 33,956 | 5.42 | Down |
 7 | Superoxide dismutase [Cu-Zn] (SOD1) | gi|27807109 | 15,844 | 5.85 | Down |
 5 | Glutathione S-transferase A1 (GSTA1) | gi|118151372 | 25,549 | 8.66 | Down |
 17 | Protein disulfide-isomerase A3 precursor (PDIA3) | gi|148230374 | 57,293 | 6.38 | Down |
Mitochondrial function (6) | |||||
 3 | Glutamate dehydrogenase 1 (GLUD1) | gi|347300243 | 61,668 | 8.03 | Up |
 6 | ATP synthase subunit beta (ATPSβ) | gi|28461221 | 56,249 | 5.15 | Down |
 8 | Aldehyde dehydrogenase (ALDH) | gi|115496214 | 57,073 | 7.55 | Up |
 10 | Cytochrom c oxidase subunit Via (COX6A1) | gi|162817 | 9, 501 | 6.13 | Down |
 13 | 60 kDa heat shock protein (HSP60) | gi|262205483 | 61,110 | 5.71 | Down |
 18 | 4-hydroxy-2-oxoglutarate aldolase (HOGA1) | gi|73998495 | 38,052 | 7.6 | Up |
Metabolism (5) | |||||
 11 | Agmatinase (AGMAT) | gi|194674166 | 39,419 | 8.77 | Up |
 12 | Acetyl-Coenzyme A acetyltransferase 2 (ACAT2) | gi|109659291 | 41,657 | 6.46 | Up |
 14 | 3-hydroxyanthranilate 3,4-dioxygenase (HAAO) | gi|115495835 | 32,701 | 5.51 | Down |
 16 | Alpha enolase (ENO1) | gi|4927286 | 47,589 | 6.44 | Up |
 4 | UMP-CMP kinase-like isoform 1 | gi|109087275 | 26,237 | 8.14 | Up |
RA metabolism (2) | |||||
 9 | Retinal dehydrogenase 1 (RALDH1) | gi|57526379 | 55,417 | 6.37 | Up |
 20 | Retinol-binding protein (RBP) | gi|415585 | 15,473 | 5.89 | Down |
Transport protein (2) | |||||
 2 | Hemoglobin subunit beta-A | gi|122540 | 16,068 | 6.75 | Down |
 15 | Albumin precursor | gi|1930850052 | 68,266 | 5.58 | Down |
Cytoskeletal structure (1) | |||||
 19 | Actin,beta | gi|148744172 | 42,022 | 5.29 | Down |