Response to an Escherichia coli K88 oral challenge and productivity of weanling pigs receiving a dietary nucleotides supplement

Table 8 The effects of dietary nucleotides supplementation on blood profiles of weaned pigs challenged with E. coli K88 (Exp. 2)^a

Item	CON	R150	R220	R275	SEM^b	Contrast^c
Item	CON	R150	R220	R275	SEM^b	1	2	3
Before Challenge
Lymphocyte, %	25.49	30.15	30.92	33.08	1.95	0.01	0.30	0.77
RBC, 10⁶/μL	6.57	6.54	7.00	6.40	0.21	0.75	0.63	0.05
WBC, 10³/μL	16.13	17.91	17.73	18.41	0.91	0.08	0.70	0.70
IgG, mg/dL	173.10	184.70	204.10	210.50	15.98	0.16	0.26	0.74
IgA, mg/dL	41.00	45.00	44.40	45.50	1.44	0.02	0.81	0.63
IgM, mg/dL	12.40	14.00	16.70	18.00	1.90	0.09	0.15	0.76
Cortisol	3.47	2.71	2.41	2.22	0.26	0.002	0.19	0.87
TNF-α	116.06	102.82	112.49	124.86	8.36	0.78	0.07	0.90
IGF-I	123.55	148.08	142.95	153.42	11.17	0.07	0.74	0.57
IL-6	19.68	20.49	20.62	19.93	0.79	0.47	0.62	0.68
After Challenge
Lymphocyte, %	29.30	19.90	29.50	30.89	5.36	0.69	0.16	0.53
RBC, 10⁶/μL	6.33	6.61	6.63	6.54	0.19	0.23	0.79	0.79
WBC, 10³/μL	17.33	23.89	18.70	20.92	1.71	0.06	0.23	0.09
IgG, mg/dL	225.50	185.10	220.80	216.40	10.60	0.15	0.05	0.13
IgA, mg/dL	41.90	42.80	44.80	46.20	0.78	0.01	0.004	0.76
IgM, mg/dL	17.30	18.40	24.00	30.00	2.00	0.01	<0.001	0.93
Cortisol	4.17	2.81	3.01	2.72	0.40	0.01	0.87	0.62
TNF-α	173.43	157.33	155.89	148.74	5.82	0.01	0.31	0.69
IGF-I	81.55	113.71	122.27	131.04	7.50	<0.001	0.11	0.99
IL-6	28.23	27.31	25.59	21.51	1.53	0.06	0.01	0.53

^aAbbreviation: CON basal diet, R150 basal diet + nucleotides 150 mg/kg, R220 basal diet + nucleotides 220 mg/kg, R275 basal diet + nucleotides 275 mg/kg
^bStandard error mean
^cContrast: 1) CON vs. mean of nucleotide groups; 2) R150 vs. R275; 3) R220 vs. mean of R150 and R275

ISSN: 2049-1891